Toshio Imai Selected Research

nimesulide (Aulin)

6/2012	Prostaglandin synthases influence thyroid follicular cell proliferation but not carcinogenesis in rats initiated with N-bis(2-hydroxypropyl)nitrosamine.
2/2006	A new medium-term rat colon bioassay applying neoplastic lesions as endpoints for detection of carcinogenesis modifiers-validation with known modifiers.

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Toshio Imai Research Topics

Disease

47	Neoplasms (Cancer) 10/2023 - 01/2002
45	Carcinogenesis 01/2023 - 01/2002
20	Body Weight (Weight, Body) 07/2022 - 07/2002
15	Inflammation (Inflammations) 05/2024 - 03/2004
15	Rheumatoid Arthritis 01/2023 - 11/2002
14	Adenocarcinoma 10/2023 - 01/2002
13	Carcinoma (Carcinomatosis) 01/2022 - 01/2002
9	Hyperplasia 01/2019 - 06/2003
8	Adenoma (Adenomas) 08/2013 - 08/2003
7	Colorectal Neoplasms (Colorectal Cancer) 01/2023 - 08/2003
6	Pancreatic Neoplasms (Pancreatic Cancer) 01/2015 - 07/2010
4	Atherosclerosis 11/2020 - 01/2004
4	Colitis 01/2019 - 06/2006
4	Periodontitis 11/2010 - 01/2003
4	Halitosis 11/2010 - 02/2008
3	Fibrosis (Cirrhosis) 05/2024 - 02/2015
3	Experimental Arthritis 03/2023 - 12/2004
3	Crohn Disease (Crohn's Disease) 08/2021 - 11/2017
3	Interstitial Lung Diseases (Interstitial Lung Disease) 05/2021 - 03/2012
3	Arthritis (Polyarthritis) 05/2021 - 05/2017
3	Stomach Neoplasms (Stomach Cancer) 01/2020 - 03/2004
3	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2019 - 09/2009
3	Aberrant Crypt Foci 08/2011 - 08/2003
3	Hypertrophy 06/2009 - 06/2003
2	Graft vs Host Disease (Graft-Versus-Host Disease) 05/2024 - 01/2007
2	Hemolysis 03/2023 - 12/2022
2	Breast Neoplasms (Breast Cancer) 10/2021 - 01/2003
2	Animal Disease Models 04/2021 - 06/2005
2	Dermatomyositis (Dermatopolymyositis) 11/2020 - 03/2012
2	Rheumatic Diseases (Rheumatism) 11/2020 - 01/2020
2	Synovitis 01/2019 - 05/2005
2	Osteoarthritis 12/2017 - 11/2002
2	Polymyositis 11/2017 - 03/2012
2	Papilloma (Papillomatosis) 01/2017 - 03/2009
2	Adenocarcinoma of Lung 11/2014 - 09/2003
2	Colonic Neoplasms (Colon Cancer) 07/2013 - 07/2013

Drug/Important Bio-Agent (IBA)

24	Chemokine CX3CL1IBA 05/2024 - 01/2004
15	Monoclonal AntibodiesIBA 05/2024 - 12/2010
11	ChemokinesIBA 08/2021 - 03/2004
10	Drinking WaterIBA 01/2017 - 08/2003
10	diisopropanolnitrosamineIBA 06/2012 - 03/2004
8	quetmolimabIBA 01/2023 - 01/2018
7	Proteins (Proteins, Gene)FDA Link 03/2023 - 06/2008
6	CarcinogensIBA 07/2022 - 12/2002
6	anthraceneIBA 10/2021 - 01/2005
6	9,10-Dimethyl-1,2-benzanthraceneIBA 05/2013 - 07/2002
6	SulfadimethoxineIBA 06/2012 - 03/2004
5	Codon (Codons)IBA 10/2021 - 09/2003
5	nitrosobis(2-oxopropyl)amine (NBOP)IBA 10/2018 - 07/2010
5	Messenger RNA (mRNA)IBA 01/2015 - 11/2004
5	SDMIBA 06/2012 - 03/2004
4	DNA (Deoxyribonucleic Acid)IBA 01/2023 - 10/2009
4	Corn Oil (Oil, Corn)IBA 01/2023 - 04/2008
4	AdipokinesIBA 10/2018 - 11/2011
4	Indomethacin (Indometacin)FDA LinkGeneric 11/2012 - 06/2006
4	Antithyroid Agents (Antithyroid Drugs)IBA 06/2012 - 03/2004
4	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 11/2010 - 12/2009
4	sodium sulfate (sodium bisulfate)FDA LinkGeneric 10/2007 - 08/2003
4	Dextrans (Dextran)FDA Link 10/2007 - 08/2003
3	AcidsIBA 01/2023 - 05/2012
3	IntegrinsIBA 01/2022 - 03/2011
3	2- amino- 1- methyl- 6- phenylimidazo(4,5- b)pyridineIBA 10/2021 - 01/2002
3	LigandsIBA 05/2021 - 11/2002
3	Cisplatin (Platino)FDA LinkGeneric 04/2020 - 01/2020
3	AzoxymethaneIBA 01/2019 - 08/2011
3	CX3C Chemokine Receptor 1IBA 11/2017 - 05/2005
3	CytokinesIBA 07/2013 - 11/2002
3	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 03/2013 - 03/2007
3	LeptinIBA 01/2012 - 08/2011
3	Methylnitrosourea (N-Methyl-N-nitrosourea)IBA 02/2010 - 12/2005
3	Capsules (Microcapsules)IBA 10/2009 - 03/2004
3	1,2-Dimethylhydrazine (1,2 Dimethylhydrazine)IBA 10/2007 - 08/2003
3	Dimenhydrinate (DMH)FDA LinkGeneric 10/2007 - 08/2003
2	RNA (Ribonucleic Acid)IBA 05/2024 - 01/2021
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 05/2024 - 01/2020
2	Gemcitabine FDA Link 10/2023 - 04/2020
2	Antirheumatic Agents (DMARD)IBA 01/2023 - 07/2021
2	Methotrexate (Mexate)FDA LinkGeneric 01/2023 - 01/2021
2	Complement System Proteins (Complement)IBA 12/2022 - 07/2013
2	CateninsIBA 07/2022 - 07/2013
2	Phenobarbital (Luminal)FDA Link 10/2021 - 01/2021
2	Estrogen ReceptorsIBA 10/2021 - 05/2013
2	Transforming Growth Factor-beta Type II ReceptorIBA 01/2021 - 01/2020
2	Irinotecan (Camptosar)FDA LinkGeneric 01/2020 - 01/2020
2	Tartrate-Resistant Acid PhosphataseIBA 01/2019 - 08/2009
2	AminesIBA 05/2018 - 01/2002
2	1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidIBA 08/2013 - 05/2012
2	Urethane (Ethyl Carbamate)IBA 08/2013 - 11/2012
2	cyclo(arginylglycyl)IBA 08/2013 - 05/2012
2	Leptin ReceptorsIBA 05/2013 - 08/2011
2	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 03/2013 - 01/2005
2	nimesulide (Aulin)IBA 06/2012 - 02/2006
2	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 06/2012 - 01/2005

Therapy/Procedure

7	Therapeutics 05/2024 - 09/2007
4	Drug Therapy (Chemotherapy) 01/2023 - 01/2015
4	Aftercare (After-Treatment) 01/2023 - 07/2013
4	Ovariectomy (Oophorectomy) 01/2007 - 07/2002
3	Subcutaneous Injections 11/2019 - 08/2003
2	Transplantation 01/2022 - 10/2014
2	Intraperitoneal Injections 08/2013 - 11/2012